Alliance for Pandemic Preparedness

September 1, 2020

Frequency of Serological Non-Responders and False-Negative RT-PCR Results in SARS-CoV-2 Testing: A Population-Based Study

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  • RT-PCR results at first clinical presentation and follow-up serology results were found to differ in about in 15% of patients suffering from nonsevere COVID-19 who had a positive test by RT-PCR and/or subsequent antibody testing. A study from Liechtenstein and Switzerland found that 12 (18%) out of 66 patients with an initial negative RT-PCR test had positive follow-up serology and 3 (4%) out of 85 initially positive RT-PCR patients had negative serology. Patients with a positive RT-PCR and negative serology tended to have longer disease duration of disease.

Baron et al. (Aug 31, 2020). Frequency of Serological Non-Responders and False-Negative RT-PCR Results in SARS-CoV-2 Testing: A Population-Based Study. Clinical Chemistry and Laboratory Medicine. https://pubmed-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/32866113