September 3, 2020

Disease Severity Dictates SARS-CoV-2-Specific Neutralizing Antibody Responses in COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Greater disease severity was associated with higher levels of serum neutralizing capacity among 59 patients recovered from COVID-19 in China. Generation of antibodies capable of completely neutralizing pseudovirus was observed in 80% of patients who recovered from severe illness, while asymptomatic patients failed to generate competent neutralizing antibodies. Complete neutralization was observed in 47% of recovered patients with moderate symptoms and 25% of those with mild symptoms.

Chen et al. (Sept 2, 2020). Disease Severity Dictates SARS-CoV-2-Specific Neutralizing Antibody Responses in COVID-19. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-020-00301-9