September 3, 2020

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• Administration of hydrocortisone, either as a 7-day fixed-dose course, or dosing only during periods of shock, was associated with being alive and free of ICU-based respiratory or cardiovascular support within 21 days, according to findings of a randomized control trial (n=384) which was stopped early after results were released from another trial. The fixed-dose course and shock-dependent dosing resulted in Bayesian probabilities of superiority of 93% and 80%, respectively.

Angus et al. (Sept 2, 2020). Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19. JAMA. https://doi.org/10.1001/jama.2020.17022