September 9, 2020

Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): clinical characteristics

• An ultra-sensitive assay can detect SARS-CoV-2 S1 subunit and nucleocapsid antigens in plasma and saliva of COVID-19 patients, with higher concentrations associated with ICU admission and intubation within one day. The authors state that while these antigens have been detected previously in nasopharyngeal swab specimens, this is the first report of their detection in plasma.

Ogata et al. (Sept 8, 2020). Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clinical Chemistry. https://doi.org/10.1093/clinchem/hvaa213