Alliance for Pandemic Preparedness

September 22, 2020

Comparison of COVID-19 Outcomes among Shielded and Non-Shielded Populations A General Population Cohort Study of 1.3 Million

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• [Pre-print, not peer-reviewed] Despite recommendations for people in the UK who were at high-risk of severe COVID-19 to shield themselves (extended self-isolation) this group experiences considerably higher COVID-19 mortality than lower risk individuals. 2.5% of the 1.3 million people included in the population study had been advised to shield, but were found to be more likely to have confirmed infections than low-risk individuals (RR=7.9), more likely to die following confirmed infection (RR=5.2), and were more likely to die from COVID-19 overall (RR=48.6). Moderate risk individuals who were not advised to shield were also more likely to die following infection and more likely to die overall, leading the authors to conclude that expanding the shielding criteria should be considered.

Jani et al. (Sept 21, 2020). Comparison of COVID-19 Outcomes among Shielded and Non-Shielded Populations A General Population Cohort Study of 1.3 Million. Pre-print downloaded Sept 22 from https://doi.org/10.1101/2020.09.17.20196436