September 22, 2020

Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers a Randomized Trial

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): health care setting, treatment

• Pre-exposure prophylaxis with hydroxychloroquine once or twice weekly did not significantly reduce laboratory-confirmed COVID-19 or COVID-19-compatible illness among healthcare workers in a randomized, double-blind, placebo-controlled clinical trial. For once weekly hydroxychloroquine prophylaxis, the hazard ratio was 0.72 (95%CI 0.44 to 1.16) and for twice weekly it was 0.74 (95%CI 0.46 to 1.19), as compared with placebo.

Rajasingham et al. (Sept 21, 2020). Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers a Randomized Trial. Pre-print downloaded Sept 22 from https://doi.org/10.1101/2020.09.18.20197327