September 22, 2020

Kinetics of SARS-CoV-2 Specific Antibodies (IgM, IgA, IgG) in Non-Hospitalized Patients Four Months Following Infection

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): immunity, testing

• Levels of antibodies against SARS-CoV-2 were found to decline over an 18-week period following symptom onset, although antibodies remained detectable. Data from longitudinal profiles of different antibody immunoglobulin classes using tests with different antigens and neutralizing titers showed that receptor-binding-domain-specific (RBD) and nucleocapsid protein-specific (NCP) IgM as well as S1-specific IgA levels significantly decreased within four months after COVID-19 onset, with RBD-specific IgM and S1-specific IgA still detectable at this time point. Furthermore, the authors reported a stronger decrease for NCP- than for S1-specific IgG antibodies and neutralizing titers, suggesting that the observed durability of SARS-CoV-2 antibody responses depends on the tests used for their assessment.

Orth-Höller et al. (Sept 18, 2020). Kinetics of SARS-CoV-2 Specific Antibodies (IgM, IgA, IgG) in Non-Hospitalized Patients Four Months Following Infection. Journal of Infection. https://doi.org/10.1016/j.jinf.2020.09.015