September 23, 2020

Risk of Adverse COVID-19 Outcomes for People Living with HIV a Rapid Review and Meta-Analysis

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• [Pre-print, not peer-reviewed] Pooled results from 5 studies (median sample size 55 [IQR 35-115]) showed that people living with HIV had a 1.9-fold higher risk of COVID-19 mortality (95%CI 1.6-2.3) compared to people without HIV. Two studies reported that tenofovir-based antiretroviral therapy regimens were associated with a lower risk of adverse COVID-19 outcomes, but the associations were confounded by comorbidities. The authors suggest further research to assess the role of antiretroviral therapy regimen, degree of immunosuppression, and viral load on COVID-19 outcomes for people living with HIV in diverse settings.

Mellor et al. (Sept 23, 2020). Risk of Adverse COVID-19 Outcomes for People Living with HIV a Rapid Review and Meta-Analysis. Pre-print downloaded Sept 23 from https://doi.org/10.1101/2020.09.22.20199661