Alliance for Pandemic Preparedness

September 24, 2020

Performance Characteristics of Five Immunoassays for SARS-CoV-2: A Head-to-Head Benchmark Comparison

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  • Four commercial and widely available SARS-CoV-2 IgG assays (Abott, DiaSorine, Roche, and Siemens), and a novel immunoassay (Oxford) were evaluated for performance using identical sample sets. All assays achieved a sensitivity ≥98% and specificity≥98% on samples taken 30 days or more post-symptom onset, based on 976 pre-pandemic blood samples collected in 2014-2016 and 536 blood samples collected from lab-confirmed COVID-19 patients.

Ainsworth et al. (Sept 23, 2020). Performance Characteristics of Five Immunoassays for SARS-CoV-2: A Head-to-Head Benchmark Comparison. The Lancet Infectious Diseases. https://doi.org/10.1016/S1473-3099(20)30634-4