Alliance for Pandemic Preparedness

September 29, 2020

Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2

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  • An analysis of ACE2 expression among 229 individuals indicated that participants who were female (OR=2.3), had hypertension (OR=1.3), had a cardiocerebrovascular disease (OR=1.3), had cancer (OR=1.7), or who were over 60 years old (OR=3.1) had higher levels of ACE2 expression, which is one of the cellular entry receptors for SARS-CoV-2. The authors suggest that persons with greater ACE2 expression may be at an increased risk of SARS-CoV-2 infection due to higher expression of ACE2.

Li et al. (Aug 19, 2020). Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2. Frontiers in Medicine. https://doi.org/10.3389/fmed.2020.00530