September 30, 2020

Angiotensin-Converting Enzyme 2 (ACE2) Levels in Relation to Risk Factors for COVID-19 in Two Large Cohorts of Patients with Atrial Fibrillation

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): candidate, report, summarize, treatment

• Male sex, cardiovascular disease, diabetes, and biomarker indicators of biological aging were associated with higher levels of soluble angiotensin-converting enzyme 2 (sACE2) among two international cohorts of elderly patients with atrial fibrillation. Higher levels of sACE2 could reflect a higher cellular expression of ACE2, a cellular receptor by which SARS-CoV-2 enters human cells, and thus pose as higher risk for severe COVID-19 infection.

Wallentin et al. (Sept 27, 2020). Angiotensin-Converting Enzyme 2 (ACE2) Levels in Relation to Risk Factors for COVID-19 in Two Large Cohorts of Patients with Atrial Fibrillation. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaa697