Alliance for Pandemic Preparedness

September 30, 2020

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers

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  • Daily administration of hydroxychloroquine to hospital-based healthcare workers as pre-exposure prophylaxis against SARS-CoV-2 infection did not change infection risk between participants receiving hydroxychloroquine vs placebo (6.3% vs 6.6%, p>0.99) in this randomized, double-blind, placebo-controlled trial (n=132).
  • The trial was terminated early due to futility and may have been underpowered to detect clinically important differences.

Abella et al. (Sept 30, 2020). Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2020.6319