Alliance for Pandemic Preparedness
October 5, 2020
Association of Corticosteroids Use and Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis
Category: Article Summary
Topic: Testing and Treatment
Keywords (Tags): treatment
- A systematic review with 1 randomized trial and 19 cohort studies (16,977 hospitalized COVID-19 patients) reported that corticosteroid therapy was not associated with a reduction in short-term mortality (RR=0.9, 95%CI 0.7-1.2) but possibly with a delay in viral clearance (RR=1.5, 95%CI 1.1-1.9). The authors call for caution in interpretation due to discordant results observed between the RCT and observational studies, as well as the heterogeneity observed across observational studies.
Tlayjeh et al. (Sept 29, 2020). Association of Corticosteroids Use and Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis. Journal of Infection and Public Health. https://doi.org/10.1016/j.jiph.2020.09.008