October 6, 2020

Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• [Pre-print, not peer reviewed] Analysis of 981 COVID-19 convalescent plasma (CP) samples from 196 donors shows that over time, neutralizing capacities of CP can decrease below recommended FDA levels of 50% neutralization (PRNT_50%) and 90% neutralization (PPRNT_90%). The most significant decreases of PRNT_50% titer occurred at more than 43 days post initial donation, suggesting a 6-week window may be optimal for collecting therapeutically effective CP.

Girardin et al. (Oct 6, 2020). Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time. Pre-print downloaded Oct 6 from https://doi.org/10.1101/2020.10.04.20206011