October 7, 2020

Antibody Reactivity to SARS-CoV-2 in Adults from the Vancouver Metropolitan Area Canada

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

• [Pre-print, not peer-reviewed] A substantial proportion of individuals who lacked serological evidence of SARS-CoV-2 exposure showed antibody reactivity against SARS-CoV-2 antigens, possibly due to cross-reactivity of antibodies against other coronaviruses. Among 276 adults tested for SARS-CoV-2 antibodies during the second wave of the COVID-19 pandemic in Vancouver, Canada (May 17-June 19, 2020), 3 participants tested positive for SARS-CoV-2 antibodies using a commercially-approved assay. Among the 273 individuals who tested negative on the commercial assay, participants showed some antibody reactivity to SARS-COV-2 RBD (7%), N protein (49%), and spike protein (82%), potentially due to cross-reactivity.

Majdoubi et al. (Oct 7, 2020). Antibody Reactivity to SARS-CoV-2 in Adults from the Vancouver Metropolitan Area Canada. Pre-print downloaded Oct 7 from https://doi.org/10.1101/2020.10.05.20206664