October 8, 2020

Extremely Potent Human Monoclonal Antibodies from Convalescent Covid-19 Patients

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): testing

• [Pre-print, not peer reviewed] Single cell sorting of 4277 SARS-CoV-2 spike protein specific memory B cells from 14 COVID-19 survivors identified 220 neutralizing antibodies that expressed as IgG. Among these, 3 monoclonal antibodies were potent enough to neutralize the wild type and DG14G mutant viruses in vitro at a concentration of <10 ng/mL, indicating they may be good candidates for further development as therapeutic tools.

Andreano et al. (Oct 7, 2020). Extremely Potent Human Monoclonal Antibodies from Convalescent Covid-19 Patients. Pre-print downloaded Oct 8 from https://doi.org/10.1101/2020.10.07.328302