Alliance for Pandemic Preparedness

October 9, 2020

Differences in Performance Characteristics Among Four High-Throughput Assays for the Detection of Antibodies Against SARS-CoV-2 Using a Common Set of Patient Samples

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  • A study comparing the performance characteristics of four high-throughput assays for SARS-CoV-2 antibody detection indicated that for samples collected from patients 14 or more days after symptom onset, the Roche and Siemens assays had the highest sensitivities (96.6% and 98.3%, respectively) and specificities (100% for both) out of the four tests. The authors note that the sensitivity and specificity of these tests would make them particularly valuable in regions with lower SARS-CoV-2 prevalence.

Manthei et al. (Oct 9, 2020). Differences in Performance Characteristics Among Four High-Throughput Assays for the Detection of Antibodies Against SARS-CoV-2 Using a Common Set of Patient Samples. American Journal of Clinical Pathology. https://doi.org/10.1093/ajcp/aqaa200