October 9, 2020

Persistence of Serum and Saliva Antibody Responses to SARS-CoV-2 Spike Antigens in COVID-19 Patients

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune

• Profiling of IgG, IgA, and IgM antibody response to the SARS-CoV-2 spike protein and its receptor-binding domain (RBD) indicated that anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva from patients with COVID-19, with peak IgG levels occurring 16 to 30 days after symptom onset. IgA and IgM antibodies rapidly decayed over time, although IgG antibodies remained relatively stable up to 105 days after symptom onset in both serum and saliva. Additionally, antibody responses to the spike protein and RBD in serum positively correlated with matched saliva samples. The authors note that based on this correlation, IgG responses in saliva may serve as a surrogate measure of systemic immunity to SARS-CoV-2.

Isho et al. (Oct 2020). Persistence of Serum and Saliva Antibody Responses to SARS-CoV-2 Spike Antigens in COVID-19 Patients. Science Immunology. https://pubmed.ncbi.nlm.nih.gov/33033173