Alliance for Pandemic Preparedness

October 9, 2020

Preemptive Interleukin-6 Blockade in Patients with COVID-19

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  • Preemptive therapy with tocilizumab to prevent the consequences of cytokine storm was associated with early favorable outcomes in 77% of patients hospitalized with COVID-19 and death occurred in 6% of treated patients in a study of 64 patients in Spain. estimated mortality of 10 to 20% in comparably ill patients. [EDITORIAL NOTE: The lack of a control group and the relatively small sample size limits the interpretability of these findings.]

Guillén et al. (Dec 8, 2020). Preemptive Interleukin-6 Blockade in Patients with COVID-19. Scientific Reports. https://doi.org/10.1038/s41598-020-74001-3