October 15, 2020

Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Geometric mean SARS-CoV-2 neutralizing antibody titers of 18 SARS-CoV-2 positive patients in South Korea decreased from 219.4 at 2 months to 143.7 at 5 months (p=0.03) after infection, indicating a waning antibody response. The decline was significantly associated with antibody levels at 2 months and happened more frequently in symptomatic patients who developed pneumonia (n=11), while none of the 7 asymptomatic participants experienced waning neutralizing antibody response.

Choe et al. (Oct 13, 2021). Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection. Emerging Infectious Diseases. https://doi.org/10.3201/eid2701.203515