Alliance for Pandemic Preparedness

October 19, 2020

Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers: A Randomized Trial

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Pre-exposure prophylaxis with hydroxychloroquine once or twice weekly did not significantly reduce COVID-19 or COVID-19-compatible illness among healthcare workers with ongoing exposure to people with SARS-CoV-2. The randomized, double-blind, placebo-controlled clinical trial of healthcare workers in the US and Canada found that for once weekly hydroxychloroquine prophylaxis, the hazard ratio for COVID-19 was 0.72 (95%CI 0.44 – 1.16), and for twice-weekly it was 0.74 (95%CI 0.46 – 1.19), as compared with placebo. 

Rajasingham et al. (Oct 17, 2020). Hydroxychloroquine as Pre-Exposure Prophylaxis for COVID-19 in Healthcare Workers: A Randomized Trial. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1571