Alliance for Pandemic Preparedness

October 19, 2020

Weak Correlation between Antibody Titers and Neutralizing Activity in Sera from SARS‐CoV‐2 Infected Subjects

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Criscuolo et al. found a poor direct correlation between anti-SARS-CoV-2 antibody titers and neutralizing activity levels against a clinical isolate of SARS-CoV-2. The authors suggest these findings highlight a need for future investigations into the role of neutralizing antibodies and their correlation with protection. In keeping with earlier studies, two commercial serology tests by DiaSorin and Roche demonstrated good sensitivity when used on samples collected from patients 15 days after hospital admission and low sensitivity for samples collected on the day of admission. The specificity evaluated for the two tests ranges from 96.5 to 100%, respectively. 

Criscuolo et al. (2020). Weak Correlation between Antibody Titers and Neutralizing Activity in Sera from SARS‐CoV‐2 Infected Subjects. Journal of Medical Virology. https://doi.org/10.1002/jmv.26605