Alliance for Pandemic Preparedness

October 21, 2020

The Effect of Prior ACEI/ARB Treatment on COVID-19 Susceptibility and Outcome: A Systematic Review and Meta-Analysis

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A systematic review and meta-analysis (49 studies) reported no association between treatment with angiotensin-converting enzyme inhibitors (ACEI) and/or angiotensin receptor blockers (ARB) and risk of SARS-CoV-2 infection (adjusted OR=1.00, 95%CI 0.94-1.05). The use of ACEI/ARB was also not associated with the risk of mortality (aOR=0.87, 95%CI 0.66-1.04) and severe outcomes (aOR=0.95, 95%CI 0.73-1.24). These findings remain consistent in subgroup analyses stratified by populations and drug exposures and in other secondary outcomes. 

Xu et al. (Oct 20, 2020). The Effect of Prior ACEI/ARB Treatment on COVID-19 Susceptibility and Outcome: A Systematic Review and Meta-Analysis. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1592