October 27, 2020

Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, summarize

A longitudinal study that followed 65 SARS-CoV-2 infected individuals up to 94 days post onset of symptoms found that the neutralizing antibody (nAb) response to SARS-CoV-2 is typical of an acute viral infection, with an initial peak whose magnitude is dependent upon disease severity, followed by declining titers. Some infected individuals with a high peak infective dose (ID₅₀ > 10,000) were found to maintain nAb titers >1,000 at >60 days post symptom onset, while some with lower peak ID₅₀ had nAbs titers similar to baseline.

Seow et al. (Oct 26, 2020). Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans. Nature Microbiology. https://doi.org/10.1038/s41564-020-00813-8