Alliance for Pandemic Preparedness

October 27, 2020

Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans

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A longitudinal study that followed 65 SARS-CoV-2 infected individuals up to 94 days post onset of symptoms found that the neutralizing antibody (nAb) response to SARS-CoV-2 is typical of an acute viral infection, with an initial peak whose magnitude is dependent upon disease severity, followed by declining titers. Some infected individuals with a high peak infective dose (ID50 > 10,000) were found to maintain nAb titers >1,000 at >60 days post symptom onset, while some with lower peak ID50 had nAbs titers similar to baseline.

Seow et al. (Oct 26, 2020). Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans. Nature Microbiology. https://doi.org/10.1038/s41564-020-00813-8