Alliance for Pandemic Preparedness

October 28, 2020

Head-to-Head Comparison of SARS-CoV-2 Antigen-Detecting Rapid Test with Self-Collected Anterior Nasal Swab versus Professional-Collected Nasopharyngeal Swab

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[Pre-print, not peer reviewed] A direct comparison between the STANDARD Q-COVID-19 Antigen Test (Ag-RDT) (Roche) and an approved RT-PCR (Roche Cobas) in samples obtained from 289 ambulatory participants demonstrated that the sensitivity of Ag-RDT with a supervised, self-collected anterior nasal swab sampling was 74.4% and specificity was 99.2%. The sensitivity with a professional-collected nasopharyngeal swab was 79.5% and specificity was 99.6%. 

Lindner et al. (Oct 27, 2020). Head-to-Head Comparison of SARS-CoV-2 Antigen-Detecting Rapid Test with Self-Collected Anterior Nasal Swab versus Professional-Collected Nasopharyngeal Swab. Pre-print downloaded Oct 28 from https://doi.org/10.1101/2020.10.26.20219600