November 3, 2020

Robust SARS-CoV-2-Specific T-Cell Immunity Is Maintained at 6 Months Following Primary Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

[Pre-print, not peer-reviewed] Blood samples from 100 convalescent donors 6 months after their initial SARS-CoV-2 infection found that T-cell responses against SARS-CoV-2 were present in all donors. The median response was 50% higher among donors with an initial symptomatic infection. T-cell responses to both spike and nucleoprotein/membrane proteins strongly correlated with peak antibody levels against each respective protein. A reduced rate of antibody level decline was strongly correlated with the magnitude of T-cell response, though this relationship was only observed for antibodies specific to the nucleoprotein.

Zuo et al. (Nov 2, 2020). Robust SARS-CoV-2-Specific T-Cell Immunity Is Maintained at 6 Months Following Primary Infection. Pre-print downloaded Nov 3 from https://doi.org/10.1101/2020.11.01.362319