November 5, 2020

Lack of Antibodies to SARS-CoV-2 in a Large Cohort of Previously Infected Persons

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

• A total of 6.3% of 2,547 healthcare workers and first responders in the New York City and Detroit metropolitan areas with previous confirmed SARS-CoV-2 infection were seronegative. Among symptomatic persons, the proportion seronegative was largely stable between 2 weeks and 90 days following symptom onset. The proportion seronegative ranged from 0% among 79 persons previously hospitalized to 11% among 308 persons with asymptomatic infections. Additionally, immunosuppressive medications, non-Hispanic white race/ethnicity, and obesity were associated with lack of antibodies.

Petersen et al. (Nov 4, 2020). Lack of Antibodies to SARS-CoV-2 in a Large Cohort of Previously Infected Persons. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1685