Alliance for Pandemic Preparedness

November 9, 2020

Differences of SARS-CoV-2 Serological Test Performance between Hospitalized and Outpatient COVID-19 Cases

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A study evaluating two commercially available SARS-CoV-2 serological assays (Virotech, VT-assays and Euroimmun, EI-assays) among using 116 COVID-19 cases (51 inpatients and 65 outpatients) reported the sensitivity of the VT-assay against IgA and IgG was markedly lower among outpatients than inpatients (IgA: 6% vs. 64%; IgG: 86% vs. 96%). The sensitivity of the EI-assay against IgA and IgG was comparable between outpatients (IgA: 97% vs. 96%; IgG: 99% vs. 92%). 

Wolf et al. (Nov 5, 2020). Differences of SARS-CoV-2 Serological Test Performance between Hospitalized and Outpatient COVID-19 Cases. Clinica Chimica Acta; International Journal of Clinical Chemistry. https://doi.org/10.1016/j.cca.2020.10.035