November 9, 2020

Preexisting and de Novo Humoral Immunity to SARS-CoV-2 in Humans

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

Using flow cytometry, SARS-CoV-2 spike glycoprotein (S)-reactive IgG antibodies were detected in 6 of 65 SARS-CoV-2-uninfected individuals (5 with RT-qPCR-confirmed seasonal human coronaviruses [HCoVs] infection and 1 without recent HCoV infection). The authors conclude that this may suggest the presence of cross-reactive immunological memory from preexisting infection rather than de novo immunity.

Ng et al. (Nov 6, 2020). Preexisting and de Novo Humoral Immunity to SARS-CoV-2 in Humans. Science. https://doi.org/10.1126/science.abe1107