November 10, 2020

Longitudinal Characterization of the IgM and IgG Humoral Response in Symptomatic COVID-19 Patients Using the Abbott Architect

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

A longitudinal analysis of 1,349 serum samples collected up to 168 days post symptom onset from 427 individuals with PCR-confirmed COVID-19 found that IgM seroconversion occurs earlier than IgG, but that IgM levels decline to a greater extent over time. The median duration of time for IgM seroconversion was 10 days, but seroprevalence declined steadily 4-5 weeks after symptom onset down to a 31% positive after 3 months. Meanwhile, median IgG seroconversion time was 11.5 days, and despite an initial decline, is observed in 92% of patients 3-6 months after symptom onset.

Maine et al. (Oct 27, 2020). Longitudinal Characterization of the IgM and IgG Humoral Response in Symptomatic COVID-19 Patients Using the Abbott Architect. Journal of Clinical Virology. https://doi.org/10.1016/j.jcv.2020.104663