Alliance for Pandemic Preparedness

November 18, 2020

Effect of Vitamin D3 Supplementation vs Placebo on Hospital Length of Stay in Patients with Severe COVID-19 A Multicenter Double-Blind Randomized Controlled Trial

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[Preprint, not peer-reviewed] Administration of a single oral dose of vitamin D3 supplementation to hospitalized patients with severe COVID-19 did not show significant effect in reducing hospital length of stay (7 days vs. 7 days, p=0.4), mortality (7% vs. 5%, p=0.6), ICU admission (16% vs. 21%; p=0.3), or mechanical ventilation requirement (7% vs 14%; p=0.1) in a multicenter, double-blind, randomized, placebo-controlled trial conducted in two centers in Brazil (n=232).

Murai et al. (Nov 17, 2020). Effect of Vitamin D3 Supplementation vs Placebo on Hospital Length of Stay in Patients with Severe COVID-19 A Multicenter Double-Blind Randomized Controlled Trial. Pre-print downloaded Nov 18 from https://doi.org/10.1101/2020.11.16.20232397