Alliance for Pandemic Preparedness

November 30, 2020

Dynamic Changes in Anti-SARS-CoV-2 Antibodies during SARS-CoV-2 Infection and Recovery from COVID-19

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An analysis of laboratory tests from 1850 patients hospitalized with COVID-19 showed changes in SARS-CoV-2 antibody levels over time, and that levels of spike protein (S)- or receptor-binding domain (RBD)-specific IgG were important in viral clearance and recovery. Generation of S-, RBD-, and nucleoprotein (N)-specific IgG occurred one week later in patients with severe COVID-19 compared to patients with mild/moderate disease, while S- and RBD-specific IgG levels were 1.5-fold higher in patients with severe disease during hospitalization. During hospitalization, RBD-specific IgG levels were 4 times higher in older patients than in younger patients. Lower S-, RBD-, and N-specific IgG levels were associated with a lower lymphocyte percentage and longer viral shedding. 

Li et al. (Dec 27, 2020). Dynamic Changes in Anti-SARS-CoV-2 Antibodies during SARS-CoV-2 Infection and Recovery from COVID-19. Nature Communications. https://doi.org/10.1038/s41467-020-19943-y