December 1, 2020

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): clinical characteristics, immunity

Among 177 SARS-CoV-2 positive individuals from the UK, 15 (9%) did not seroconvert during the entire 60-day follow-up period, suggesting that a minority of infected persons may not develop detectable IgG against SARS-CoV-2. Persons who seroconverted were older compared to those who did not seroconvert (median age 66 vs 41 years) and were more likely to have comorbidities and higher levels of inflammatory markers. 

Staines et al. (Nov 30, 2021). IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Emerging Infectious Diseases. https://doi.org/10.3201/eid2701.203074