December 4, 2020

Durability of Responses after SARS-CoV-2 MRNA-1273 Vaccination

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccines

• Immunogenicity data from 24 participants obtained at 119 days after initial vaccination (90 days after second vaccination) with the mRNA-1273 SARS-CoV-2 vaccine (Moderna) indicated that the vaccine produced high levels of binding and neutralizing antibodies that declined slightly over time, but remained elevated in all participants 3 months after the booster vaccination. Serum neutralizing antibodies were still detected in all the participants at day 119. No serious adverse events were noted in the trial, and no new adverse events that were considered by the investigators to be related to the vaccine occurred after day 57.

Widge et al. (Dec 3, 2020). Durability of Responses after SARS-CoV-2 MRNA-1273 Vaccination. New England Journal of Medicine. https://doi.org/10.1056/NEJMc2032195