Alliance for Pandemic Preparedness

December 8, 2020

Defining the Features and Duration of Antibody Responses to SARS-CoV-2 Infection Associated with Disease Severity and Outcome

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Analysis of 983 longitudinal plasma samples from 254 SARS-CoV-2 infected individuals with varying disease severity show that compared to severely ill patients, outpatients with mild illness had higher titers of IgG antibodies targeting the S1 domain or receptor binding domain (RBD) of the SARS-CoV-2 spike protein than of those targeting the nucleocapsid antigen. Neutralization assays correlated well with patient IgG titers to the RBD. 

Röltgen et al. (Dec 7, 2020). Defining the Features and Duration of Antibody Responses to SARS-CoV-2 Infection Associated with Disease Severity and Outcome. Science Immunology. https://doi.org/10.1126/sciimmunol.abe0240