Alliance for Pandemic Preparedness

December 8, 2020

Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19

Category:

Topic:

Keywords (Tags): ,

Being critically ill was an independent risk factor of longer PCR-confirmed viral positivity in a retrospective study of 2,142 COVID-19 patients in Wuhan, China. The observed median duration of PCR-confirmed viral positivity was 24 days among critically ill patients and 18 days among non-critically ill-patients, with 20% of samples remaining positive after 5 weeks. Seroconversion rates peaked within 4 to 5 weeks, but low IgM titers were observed among those with persistent viral positivity.

Fu et al. (Dec 8, 2020). Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19. Annals of Internal Medicine. https://doi.org/10.7326/M20-3337