Alliance for Pandemic Preparedness
December 11, 2020
Multicenter Evaluation of the Clinical Performance and the Neutralizing Antibody Activity Prediction Properties of ten high throughput serological assays used in Clinical Laboratories
Category: Article Summary
Topic: Testing and Treatment
Keywords (Tags): testing
- In a study evaluating ten enzyme immunoassays and three lateral flow chromatography assays, seven immunoassays were shown to have excellent specificity (98 to 100%) and good to excellent positive predictive values (82 to 100%) when used in a low (5%) seroprevalence setting. Sensitivity values as low as 74% and as high as 95% at ≥15 days post symptom onset were observed.
Therrien et al. (Dec 10, 2020). Multicenter Evaluation of the Clinical Performance and the Neutralizing Antibody Activity Prediction Properties of ten high throughput serological assays used in Clinical Laboratories. Journal of Clinical Microbiology.