Alliance for Pandemic Preparedness

December 16, 2020

All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020

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The COVID-19 pandemic was associated with increases in all-cause mortality among US adults aged 25-44 from March to July of 2020. 38% of all-cause excess deaths in this age group were attributed directly to COVID-19, and while the remaining excess deaths are unexplained, the authors posit that inadequate SARS-CoV-2 testing likely contributed to the discrepancy. During surges in COVID-19 in HHS Region 2 (New York, New Jersey), the incident rate of all-cause mortality was increased by 130% relative to pre-pandemic levels and 80% of deaths were related to COVID-19. In Region 6 (Arkansas, Louisiana, New Mexico, Oklahoma, Texas) there was a 46% increase in the mortality rate and 48% were related to COVID-19. In Region 9 (Arizona, California, Hawaii, Nevada) there was a 47% increase in mortality and 40% were attributed to COVID-19. Deaths due to COVID-19 were similar to or exceeded unintentional opioid deaths that occurred during several corresponding months in 2018 in several regions.

Faust et al. (Dec 16, 2020). All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2774445