December 16, 2020

Clinical, Laboratory, and Temporal Predictors of Neutralizing Antibodies to SARS-CoV-2 among COVID-19 Convalescent Plasma Donor Candidates

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

A study assessing the durability of neutralizing antibody responses (nAb) and factors to streamline plasma donor selection found that nAb titers correlated with COVID-19 severity (aOR=6.59), age (aOR=1.03 per year), and male sex (aOR=2.08). Functional levels declined over time and a small number of individuals (2.8%) who recovered from COVID-19 lacked adaptive immune responses. Of 250 people studied a mean of 67 days after symptom onset, 97% were seropositive on at least one assay. 

Boonyaratanakornkit et al. (Dec 15, 2020). Clinical, Laboratory, and Temporal Predictors of Neutralizing Antibodies to SARS-CoV-2 among COVID-19 Convalescent Plasma Donor Candidates. Journal of Clinical Investigation. https://doi.org/10.1172/JCI144930