Alliance for Pandemic Preparedness

January 6, 2021

The Duration, Dynamics and Determinants of SARS-CoV-2 Antibody Responses in Individual Healthcare Workers

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A longitudinal SARS-CoV-2 seroprevalence study of healthcare workers in the United Kingdom found peak IgG antibody levels to SARS-CoV-2 nucleocapsid was 24 days following the first positive PCR test with a mean antibody half-life of 85 days. Antibodies waned faster in younger adults and those without symptoms. Anti-spike IgG levels remained stably detected after a positive result in 94% of individuals at 180 days. Higher maximum observed anti-nucleocapsid titers were associated with longer estimated antibody half-lives. Increasing age, Asian ethnicity and prior self-reported symptoms were independently associated with higher maximum anti-nucleocapsid levels; increasing age and a positive PCR test undertaken for symptoms were associated with longer anti-nucleocapsid half-lives.

Lumley et al. (Jan 6, 2021). The Duration, Dynamics and Determinants of SARS-CoV-2 Antibody Responses in Individual Healthcare Workers. Clinical Infectious Diseases.  https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab004/6064824