January 7, 2021

Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

IgG antibodies against the Spike protein and the receptor binding domain (RBD) were relatively stable over 6 months in a cohort study of individuals with confirmed COVID-19 (n=188). Among 40 individuals with blood samples 6-8 months post-symptom onset, 90%, 88%, and 90% remained seropositive for anti-spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Paired timepoint analysis showed that anti-spike and anti-RBD IgG declined with a half-life of 68 and 69 days, respectively. Spike-specific memory B cells were more abundant at 6 months than at 1 month post-symptom onset, while SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months.

Dan et al. (Jan 6, 2021). Immunological Memory to SARS-CoV-2 Assessed for up to 8 Months after Infection. Science. https://doi.org/10.1126/science.abf4063