Alliance for Pandemic Preparedness

January 11, 2021

Prevalence and Clinical Significance of Persistent Viral Shedding in Hospitalized Adult Patients with SARS-CoV-2 Infection: A Prospective Observational Study

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A prospective observational study of adults hospitalized with SARS-CoV-2 infection (n=121) detected persistent viral shedding (PVS) for at least 21 days in up to 38% of patients, which was strongly associated with immunosuppression (6.7% vs 21.7%), increased IL-6 levels (43.4% vs 67.3%), and need for mechanical ventilation (20.0% vs 41.3%). Time from onset of symptoms was also an independent factor associated with PVS in the multivariate analysis.

Vena et al. (Jan 8, 2021). Prevalence and Clinical Significance of Persistent Viral Shedding in Hospitalized Adult Patients with SARS-CoV-2 Infection: A Prospective Observational Study. Infectious Diseases and Therapy. https://doi.org/10.1007/s40121-020-00381-8