Alliance for Pandemic Preparedness

January 22, 2021

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021

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Between December 21, 2020 and January 10, 2021, monitoring by the Vaccine Adverse Event Reporting System detected ten cases of anaphylaxis after administration of a reported 4,041,396 first doses of the Moderna COVID-19 vaccine in the US. In nine cases, onset occurred within 15 minutes of vaccination. Nine of the ten cases of anaphylaxis occurred in people with histories of allergies or allergic reactions, and five occurred in people with a previous history of anaphylaxis. Among the eight people for whom follow-up information was available, all had recovered or been discharged home, and no anaphylaxis-related deaths were reported.

Among the 43 cases of non-anaphylaxis allergic reactions, 26 (60%) were classified as nonserious. Reactions included itching, rash, itchy sensations in the mouth and throat, sensations of throat closure, and respiratory symptoms.

CDC COVID-19 Response Team. (Jan 22, 2021). Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021. MMWR. http://dx.doi.org/10.15585/mmwr.mm7004e1