January 26, 2021

Longitudinal Analysis of Humoral Immunity against SARS-CoV-2 Spike in Convalescent Individuals up to 8 Months Post-Symptom Onset

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

[Pre-print, not peer-reviewed] A longitudinal study of 101 blood samples from 32 people recovering from COVID-19 found that memory B cells for anti-receptor binding domain (RBD) IgG antibodies increase over time and persist for up to 8 months post-symptom onset. Detectable IgG and sustained Fc-effector activity in plasma was also observed up to 8 months, despite IgG levels decaying over time. In contrast, levels of RBD-specific IgM memory B cells and IgM antibodies waned much more rapidly than their IgG counterparts.

Anand et al. (Jan 25, 2021). Longitudinal Analysis of Humoral Immunity against SARS-CoV-2 Spike in Convalescent Individuals up to 8 Months Post-Symptom Onset. Pre-print downloaded Jan 26 from https://doi.org/10.1101/2021.01.25.428097