January 27, 2021

Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, immunity

[Pre-print, not per-reviewed] A longitudinal study of people who had recovered from COVID-19 (n=963) estimated a half-life of 7.7 months for anti-spike IgG and a half-life of 8.7 months for serum neutralization, with only 13% of individuals losing seroreactivity at ten months. In addition, around 3% of recovered patients demonstrated effective cross-neutralizing IgG antibodies to SARS-CoV-1 without known prior exposure to the virus. Key factors in predicting the development of SARS-CoV-2 neutralizing activity in mild cases were seroreactivity, age, time since disease onset, and fever. 

Vanshylla et al. (Jan 26, 2021). Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2. Pre-print downloaded January 27 from https://doi.org/10.1101/2021.01.26.428207