Alliance for Pandemic Preparedness

January 29, 2021

The effect of SARS-CoV-2 variant B.1.1.7 on symptomatology re-infection and transmissibility

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[Pre-print, not peer-reviewed] No association was found between the proportion of the UK SARS-CoV-2 variant B.1.1.7 in circulation and reported disease severity, according to data obtained from reporting of symptoms and test results via the COVID Symptom Study application. The authors controlled for both demographic characteristics (age, sex) and seasonal variables (temperature, humidity). No effects were observed based on the number of different reported symptoms, hospitalizations, frequency any of the individual symptoms, or the proportion of individuals with long symptom duration (≥28 days). The proportion of individuals with duration of symptoms ≥28 days did not change in association with the presence of the B.1.1.7 variant. The proportion of users with asymptomatic disease did not significantly change as B.1.1.7 increased in prevalence.

Graham et al. (Jan 29, 2021). The effect of SARS-CoV-2 variant B.1.1.7 on symptomatology re-infection and transmissibility. Pre-print downloaded Jan 29 from https://doi.org/10.1101/2021.01.28.21250680