February 1, 2021

Impact of Age Gender Ethnicity and Prior Disease Status on Immunogenicity Following Administration of a Single Dose of the BNT162b2 MRNA Covid-19 Vaccine Real-World Evidence from Israeli Healthcare Workers December-January 2020

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, vaccines

[Pre-print, not peer-reviewed] Among 514 healthcare workers in Israel who received a SARS-CoV-2 vaccine (majority Pfizer), 92% had detectable IgG antibodies 21 days post-vaccination. There was no statistically significant difference in antibody titers between males and females or by ethnicity, but titers decreased with increasing age. Individuals with prior COVID-19 who received the vaccine had IgG titers at least one order of magnitude higher than those who had no prior infection, regardless of whether neutralizing antibodies were detectable immediately prior to vaccination.

Jabal et al. (Jan 31, 2021). Impact of Age Gender Ethnicity and Prior Disease Status on Immunogenicity Following Administration of a Single Dose of the BNT162b2 MRNA Covid-19 Vaccine Real-World Evidence from Israeli Healthcare Workers December-January 2020. Pre-print downloaded Feb 1 from https://doi.org/10.1101/2021.01.27.21250567