February 1, 2021

Robust Spike Antibody Responses and Increased Reactogenicity in Seropositive Individuals after a Single Dose of SARS-CoV-2 MRNA Vaccine

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, vaccines

[Pre-print, not peer-reviewed] One dose of mRNA vaccine elicited a rapid and strong immune response among individuals already seropositive for SARS-CoV-2, with antibody titers 10-20 times higher than those of naïve vaccinees at the same timepoint. Seropositive individuals also had antibody titers that exceeded by >10-fold the median titers among individuals without previous infection who received two doses of the vaccine. Among 109 individuals who received their first vaccine dose in 2020, variable and low IgG responses were observed 9-12 days after vaccination among those who were seronegative(n=68), while uniformly high antibody titers were observed within 5-8 days among those who were seropositive (n=41). 

Krammer et al. (Jan 1, 2021). Robust Spike Antibody Responses and Increased Reactogenicity in Seropositive Individuals after a Single Dose of SARS-CoV-2 MRNA Vaccine. Pre-print downloaded Feb 1 from https://www.medrxiv.org/content/10.1101/2021.01.29.21250653v1