Alliance for Pandemic Preparedness

February 5, 2021

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates

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[Pre-print, not peer reviewed] An analysis of SARS-CoV-2 genome sequences from around the world found that the overall rate of non-synonymous mutations in the spike protein was low. While only 14% of the samples contained no variation from the reference sequence, fewer than 10 non-synonymous mutations were found in 99.98% of samples. Recurrent variations were common and were distributed throughout the spike genome. The mean and median number of spike protein mutations per sample increased over time, however.

Schroers et al. (Feb 4, 2021). Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates. Pre-print downloaded Feb 5 from https://doi.org/10.1101/2021.02.04.429765